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KMID : 0370220180620020118
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Yakhak Hoeji
2018 Volume.62 No. 2 p.118 ~ p.125
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Effects of natural products derived from Acanthopanax divaricatus var. albeofructus including coniferin on gene expression and production of MUC5AC mucin from human airway epithelial cells
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Lee Hyun-Jae
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Abstract
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We investigated whether coniferin, tortoside A, eleutheroside E or salvadoraside derived from Acanthopanax divaricatus var. albeofructus affects airway MUC5AC mucin gene expression and production induced by epidermal growth factor(EGF) from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with EGF for 24h. The four compounds inhibited the gene expression and production of MUC5AC mucin from NCI-H292 cells. This result suggests that the four compounds can inhibit the production and gene expression of mucin induced by EGF, through directly acting on airway epithelial cells.
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KEYWORD
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airway, mucin, coniferin
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